Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review

Jakobsen, Nadia; Weber, Nicolai Rosager; Larsen, Inge; Pedersen, Ken Steen

doi:10.1186/s13028-024-00766-6

Acta Veterinaria Scandinavica

Table 1 Overview of studies on acute phase protein (APP) levels in pigs for experimentally induced diseases¹

From: Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review

Reference	Age group²	Disease³	Investigated APPs⁴
[36]	GP	Swine influenza (H1N1) AP H1N1 + AP	SAA, MAP, HP, CRP SAA, MAP, HP, CRP SAA, MAP, HP, CRP*
[35]	GP	Swine influenza (H1N1) + B. bronchiseptica	SAA* (40-fold increase), MAP* (Threefold increase), HP* (Fivefold increase), CRP* (Eightfold increase)
[31]	GP	Swine influenza (H1N1) + P. multocida	SAA* (40-fold increase), MAP* (Fourfold increase), HP* (Fourfold increase), CRP* (Eightfold increase)
[30]	GP	Swine influenza (H3N2) + P. multocida	SAA* (50-fold increase), MAP* (Threefold increase), HP* (Sixfold increase), CRP* (Fivefold increase)
[34]	GP	Swine influenza (H3N2) + B. bronchiseptica	SAA* (30-fold increase), MAP* (Threefold increase), HP* (Sevenfold increase), CRP* (Eightfold increase)
[33]	GP	P. multocida	SAA* (30-fold increase), MAP* (Fourfold increase), HP* (Fivefold increase), CRP* (Eightfold increase)
[32]	GP	B. bronchiseptica	SAA* (30-fold increase), MAP* (Threefold increase), HP* (Fivefold increase), CRP* (Eightfold increase), AGP
[28]	GP	PRRS	CRP, HP (both saliva and serum)
[27]	GP	PRRS	AGP, HP*
[26]	GP	S. suis	SAA* (40-fold increase), Pig-MAP* (Sevenfold increase), HP* (Tenfold increase), CRP* (Tenfold increase), Apo A-I* (40% reduction), Alb
[39]	FP	AP	CRP, HP
[37]	FP	AP	CRP* (Sevenfold increase), HP* (40-fold increase), MAP* (12—fold increase)
[38]	FP	AP	CRP* (13-fold increase), HP, SAA* (89-fold increase),
[42]	FP	ASF ADV	MAP, CRP, HP, Alb MAP, CRP, HP, Alb
[40]	FP	S. suis	HP* (12-fold increase)
[41]	FP	Osteomyelitis (S. aureus)	HP, CRP, SAA
[43]	S	Intramammary inoculation of E. coli	SAA* (Tenfold increase), HP

¹Acute phase proteins marked with * differ significantly pre and post infection (P < 0.05)
²GP Growing pigs (weaning to 10 weeks of age), FP Finishing pigs (10 weeks—slaughter), S = Sows (1 + parities)
³AP Actinobacillus pleuropneumoniae, PRRS Porcine respiratory and respiratory syndrome, ASF African swine fever, ADV Aujeszky’s disease
⁴CRP C-reactive protein (μg/mL), SAA Serum Amyloid A (μg/mL), HP Haptoglobin (mg/mL), MAP Pig major acute phase protein (mg/mL), Alb Albumin (g/dL), Apo A-I Apo lipoprotein A-I (mg/mL)

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ISSN: 1751-0147

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