Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review

Table 9 Receiver operating curve data calculated for mastitis using different acute-phase proteins (APPs)¹

	Reference	APP²	Cut-off	Sen (%)	Spec (%)	AUC
Subclinical mastitis	[77]	Alb	0.038	88.5	86.8	0.93
	[77]	MAA	1.6	92.3	92.1	0.98
	[76]	MAA	16.4	90.6	98.3	0.99
	[73]	MAA	0.317	100	100	–
	[82]	MAA	10.0	90	56.66	0.85
	[76]	SAA	159.1	90.0	72.1	0.84
	[73]	SAA	1.99	100	100	–
	[82]	SAA	74.0	100	93.33	1.0
	[76]	Milk HP	0.004	90.6	68.6	0.89
	[73]	Milk HP	0.056	100	100	–
	[76]	Serum HP	0.05	90.0	64.43	0.78
	[73]	Serum HP	0.03	90.0	100	–
Clinical mastitis	[115]	SAA	9.6	83.0	90.0	–
	[116]	SAA	26.41	79.2	95.0	0.95
	[115]	Serum HP	0.05	82.0	94.0	–
	[116]	Serum HP	0.09	86.8	80.0	0.93
	[115]	MAA	0.55	93.0	100	–
	[115]	Milk HP	0.02	86.0	100	-

¹Sen Sensitivity (%), Spec specificity (%), AUC area under the curve
²Alb Albumin (g/dL), SAA Serum Amyloid A (μg/mL), MAA Milk Amyloid A (μg/mL), HP Haptoglobin (mg/mL)

ISSN: 1751-0147