Fig. 2

Parallel Tukey boxplots of the rectal temperature in pigs. The boxplot covers the acclimatization period (Day –5 to Day 0) and the first five days after inoculation (Day 0) with Actinobacillus pleuropneumonia serotype 2. Temperatures included in ‘Day 1’ range from ~ 6 h post-inoculation to 24 h post-inoculation; subsequent measurements were taken at ~ 24-h intervals. Benzylpenicillin treatment was initiated at the onset of clinical signs which occurred within 24 h after inoculation. The treatment group nomenclature is: the medicinal product, either procaine benzylpenicillin in a water suspension (ETH) or procaine benzylpenicillin in an oil suspension (UPA); dose in mg/kg; dose frequency (once or twice daily) and treatment duration in days. For example, ETH20-2 × 3 should read as: procaine benzylpenicillin in a water suspension 20 mg/kg bodyweight twice daily for three days